The College of Arts and Sciences at the University of Missouri–St. Louis and its Department of Criminology and Criminal Justice host the AE21: American Exceptionalism in the 21st Century conference, April 25-26 at UMSL’s J.C. Penney Building/Conference Center. Presentations and discussions examine the contemporary relevance and validity of the exceptionalism thesis as applied to a variety of institutions in the United States and other developed nations.